Mhedzisiro Yetsvagiridzo yeMaviri kana mana Majekiseni ePlatelet-rich Plasma muOsteoarthritis Knee.

Majekiseni maviri kana mana eplatelet-rich plasma mubvi reosteoarthritis haana kushandura synovial biomarkers, asiwo akavandudza mhedzisiro yekiriniki.

Zvinoenderana nekuyedzwa kwenyanzvi dzeindasitiri dzakakodzera, vakafananidza majekiseni maviri uye mana e-intra-articular e-platelet-rich plasma (PRP) maererano nekuchinja kwe synovial cytokines uye mhedzisiro yekiriniki.Varwere 125 vane knee osteoarthritis (OA) vakagamuchira majekiseni ePRP mavhiki matanhatu ose.Pamberi pejekiseni rega rega rePRP, zvishuvo zve synovial fluid zvakaunganidzwa kuti zvidzidze.Varwere vakakamurwa kuva maviri kana mana intra-articular PRP majekiseni (mapoka A uye B, zvichiteerana).Shanduko mu synovial biomarkers dzakafananidzwa nemazinga ekutanga mumapoka maviri, uye mhedzisiro yekiriniki yakaongororwa kusvika gore rimwe.

Varwere makumi mapfumbamwe nevana vakapedza synovial fluid collection vakabatanidzwa mukuongororwa kwekupedzisira, 51 muboka A uye 43 muboka B. Pakanga pasina misiyano muzera rinorehwa, zvepabonde, body mass index (BMI), uye radiographic OA grade.Izvo zvinoreva platelet count uye white blood cell count muPRP yaiva 430,000 / µL uye 200 / µL, maererano.Synovial inflammatory cytokines (IL-1β, IL-6, IA-17A, uye TNF-α), anti-inflammatory cytokines (IL -4, IL-10, IL-13, uye IL-1RA) yakanga isina kuchinjwa, uye kukura Zvinhu (TGF-B1, VEGF, PDGF-AA uye PDGF-BB) vaiva pakutanga uye pakati pevhiki dze6 muGroup A uye vhiki dze18. muGroup B.

Zvigumisiro zvemakiriniki mumapoka ose maviri zvakavandudzwa zvakanyanya kubva kumavhiki e6, kusanganisira Visual Analog Scale (VAS), Murwere Akaremerwa Migumisiro Yezviyero [PROMs;Western Ontario uye McMaster Universities Osteoarthritis (WOMAC) Index uye Short Form-12 (SF-12)], maitiro-based zviyero [PBMs;nguva yekusimuka (TUG), 5 sit-stand tests (5 × SST), uye 3-minute kufamba miedzo (3-minute WT)] .Pakupedzisira, 2 kana 4 intra-articular injections ye PRP mavhiki ose e6 mumabvi OA haina kuratidza shanduko mu synovial cytokines uye kukura kwezvinhu, asiwo yakavandudza mhedzisiro yekiriniki kubva kumavhiki matanhatu kusvika 1 gore.