Nezve Platelet Rich Plasma (PRP)
Platelet-rich plasma (PRP) ine inofananidzwa yekurapa kukosha kune stem maseru uye parizvino ndeimwe yeanovimbisa kurapa mishonga mukurapa kwekuvandudza.Iri kuwedzera kushandiswa munzvimbo dzakasiyana dzekurapa, kusanganisira cosmetic dermatology, orthopedics, mishonga yemitambo uye kuvhiyiwa.
Muna 1842, zvimwe zvimiro kunze kwemasero matsvuku nemachena eropa zvakawanwa muropa, izvo zvakashamisa vakararama panguva yake.Julius Bizozero ndiye akatanga kutumidza chimiro chitsva cheplatelet "le piastrine del sangue" - maplatelet.Muna 1882, akatsanangura basa remaplatelet mu coagulation in vitro uye kubatanidzwa kwavo mu etiology ye thrombosis mu vivo.Akaona zvakare kuti madziro emidziyo yeropa anodzivirira kunamatira kweplatelet.Wright akawedzera kufambira mberi mukuvandudza nzira dzekurapa patsva nekuwana kwake macrokaryocytes, anove anotangira maplatelet.Mukutanga kwe1940s, varapi vakashandisa "embryonic" zvinyorwa zvinoumbwa nekukura zvinhu uye cytokines kukurudzira kuporeswa kwemaronda.Kurumidza uye kupora maronda kunokosha pakubudirira kwekuvhiya.Naizvozvo, Eugen Cronkite et al.yakaunza musanganiswa we thrombin uye fibrin mune ganda grafts.Nokushandisa zvikamu zviri pamusoro apa, kusungirirwa kwakasimba uye kwakagadzikana kwevhavha kunovimbiswa, iyo inoita basa rinokosha mumhando iyi yekuvhiya.
Mukuvamba kwezana ramakore rechi 20, varapi vakaziva kudikanwa kwokukurumidzira kupinza ropa replatelet kurapa thrombocytopenia.Izvi zvakakonzera kuvandudzwa kweplatelet concentrate kugadzirira matekiniki.Kuwedzera neplatelet concentrates kunogona kudzivirira kubuda ropa muvarwere.Panguva iyoyo, varapi nevarabhoritari vanoongorora hematologist vakaedza kugadzira maplatelet concentrates nokuda kwekuwedzerwa ropa.Nzira dzekuwana maconcentrates dzakagadzirwa nekukurumidza uye dzakavandudza zvakanyanya, sezvo mahwendefa ari oga anokurumidza kurasikirwa nekugona uye anofanirwa kuchengetwa pa4 ° C uye kushandiswa mukati me24 h.
Zvishandiso uye Nzira
Mumakore ekuma1920, citrate yakashandiswa seanticoagulant kuwana maplatelet concentrates.Kufambira mberi mukugadzirira kweplatelet concentrate kwakawedzera mu1950s uye 1960s apo midziyo yeropa inochinjika yepurasitiki yakagadzirwa.Izwi rokuti "platelet-rich plasma" yakatanga kushandiswa naKingsley et al.muna 1954 kureva maplatelet concentrates akajairika anoshandiswa pakuwedzerwa ropa.Bhangi rekutanga reropa rePRP maumbirwo akaonekwa muma1960 uye akave akakurumbira muma1970.Mukupera kwema1950 nema1960, “EDTA platelet packs” yakashandiswa.Iyo seti ine bhegi repurasitiki rine EDTA ropa rinobvumira maplatelet kuti aiswe ne centrifugation, iyo inoramba yakamiswa muchikamu chidiki cheplasma mushure mekuvhiyiwa.
Mhedzisiro
Zvinofungidzirwa kuti kukura zvinhu (GFs) mamwe makomisheni ePRP anovanzwa kubva kumaplatelet uye anobatanidzwa mukuita kwayo.Iyi fungidziro yakasimbiswa muma1980s.Zvinoitika kuti maplatelet anoburitsa bioactive molecules (GFs) kugadzirisa matishu akakuvadzwa, senge maronda eganda.Kusvika iye zvino, zvidzidzo zvishomanana zvekuongorora nyaya iyi zvakaitwa.Imwe yezvidzidzo zvakadzidzwa mundima iyi ndeyekusanganiswa kwePRP uye hyaluronic acid.Epidermal growth factor (EGF) yakawanikwa naCohen mu 1962. MaGF akatevera aiva platelet-derived growth factor (PDGF) mu1974 uye vascular endothelial growth factor (VEGF) mu1989.
Pakazara, kufambira mberi mukurapa kwakakonzerawo kufambira mberi nekukurumidza mukushandiswa kweplatelet.Muna 1972, Matras akatanga kushandisa maplatelet sechisimbiso kumisikidza ropa homeostasis panguva yekuvhiya.Uyezve, muna 1975, Oon naHobbs vaive vekutanga masayendisiti kushandisa PRP mukurapa kwekuvaka.Muna 1987, Ferrari et al akatanga kushandisa platelet-rich plasma seautologous sosi yekuwedzerwa ropa mukuvhiyiwa kwemoyo, nekudaro ichidzikisa kurasikirwa kweropa, kusagadzikana kweropa kweperipheral pulmonary circulation, uye kushandiswa kwakatevera kwezvigadzirwa zveropa.
Muna 1986, Knighton et al.vaive masayendisiti ekutanga kutsanangura chirongwa chekuwedzera kweplatelet ndokuchitumidza kuti autologous platelet-derived ronda healing factor (PDWHF).Kubva pakagadzwa protocol, iyo tekinoroji yave kuwedzera kushandiswa mukurapa aesthetic.PRP yakashandiswa mukurapa kwekuvandudza kubva pakupera kwema1980.
Pamusoro pekuvhiyiwa kwese uye kuvhiyiwa kwemoyo, kuvhiyiwa kwemaxillofacial yaive imwe nzvimbo iyo PRP yakave yakakurumbira mukutanga kwe1990s.PRP yakashandiswa kuvandudza kusungirirwa kwegraft mukuvakazve mandibular.PRP yakatangawo kushandiswa mukurapa mazino uye yakashandiswa kubva pakupera kwe1990s kuvandudza kusungirirwa kwemazino ekudyara uye kukurudzira kuvandudzwa kwemapfupa.Pamusoro pezvo, fibrin glue yaive chinhu chaizivikanwa chine hukama chakaunzwa panguva iyoyo.Kushandiswa kwePRP mukurapa mazino kwakagadziridzwa zvakare nekugadzirwa kweplatelet-rich fibrin (PRF), platelet concentrate isingadi kuwedzerwa kwe anticoagulants, neChoukroun.
PRF yakawedzera kufarirwa mukutanga kwe2000s, nenhamba inowedzera yezvikumbiro mumaitiro emazino, kusanganisira kuvandudzwa kwe hyperplastic gingival tissue uye periodontal kuremara, palatal ronda kuvharwa, gingival recession kurapwa, uye kudhonza maoko.
Kurukurai
Anitua mu1999 akatsanangura kushandiswa kwePRP kukurudzira kuvandudzwa kwepfupa panguva yekuchinjana kweplasma.Mushure mekuona kubatsira kwekurapa, masayendisiti akaongororazve chiitiko ichi.Mapepa ake akatevera akashuma mhedzisiro yeropa iri pamaronda eganda asingaperi, kuisirwa mazino, kuporesa tendon, uye kukuvara kwemitambo yemapfupa.Mishonga yakawanda inoita PRP, yakadai se calcium chloride uye bovine thrombin, yakashandiswa kubvira 2000.
Nekuda kwehunhu hwayo hwakanaka, PRP inoshandiswa mune orthopedics.Migumisiro yekutanga yekudzidza kwakadzika kwemigumisiro yekukura kwezvinhu pamatendo emunhu yakabudiswa mu 2005. PRP therapy ikozvino inoshandiswa kurapa zvirwere zvinopera uye kukurudzira kuporesa kwetendon, ligaments, muscles uye cartilage.Tsvagiridzo inoratidza kuti kuenderera mberi kwekufarirwa kwemaitiro mu orthopedics kunogona zvakare kuve kwakabatana nekushandiswa kazhinji kwePRP nevemitambo nyeredzi.Muna 2009, chidzidzo chemhuka chekuedza chakabudiswa icho chakasimbisa pfungwa yokuti PRP inotarisa kuvandudza mishonga yemasumbu.Icho chiri pasi pemaitiro ePRP chiito muganda iye zvino ndiyo nyaya yekutsvakurudza kwakasimba kwesayenzi.
PRP yakashandiswa zvinobudirira mucosmetic dermatology kubvira 2010 kana mberi.Mushure mekuisa jekiseni PRP, ganda rinotaridzika diki uye hydration, kuchinjika uye ruvara zvinovandudzwa zvakanyanya.PRP inoshandiswawo kuvandudza kukura kwebvudzi.Kune marudzi maviri ePRP ikozvino anoshandiswa kurapa bvudzi kukura - inactive platelet-rich plasma (A-PRP) uye inoshanda-platelet-rich plasma (AA-PRP).Zvisinei, Vemamwe Marudzi et al.yakaratidza kuti kusimba kwebvudzi uye kuverengera kwebvudzi paramita kunogona kuvandudzwa nekubaya jekiseni A-PRP.Pamusoro pezvo, zvave zvichiratidzwa kuti kushandisa PRP kurapwa kusati kwaitwa bvudzi kunogona kuwedzera kukura kwebvudzi uye kuwanda kwebvudzi.Mukuwedzera, muna 2009, zvidzidzo zvakaratidza kuti kushandiswa kwemusanganiswa wePRP nemafuta kunogona kuvandudza kugamuchirwa kwemafuta uye kurarama, izvo zvinogona kuwedzera kuvhiyiwa kwepurasitiki.
Zvichangoburwa zvakawanikwa kubva kuCosmetic Dermatology zvinoratidza kuti musanganiswa wePRP uye CO2 laser therapy inogona kuderedza mavanga eacne zvakanyanya.Saizvozvo, PRP uye microneedling yakaguma yakarongeka yakawanda collagen masumbu muganda kupfuura PRP chete.Nhoroondo yePRP haisi pfupi, uye zvakawanikwa zvine chokuita nechikamu ichi cheropa zvakakosha.Makiriniki nemasayendisiti vari kushingaira kutsvaga nzira itsva dzekurapa.Senzira, PRP inoshandiswa munzvimbo dzakawanda dzemishonga, kusanganisira gynecology, urology, uye ophthalmology.
Nhoroondo yePRP inenge iine makore makumi manomwe.Nokudaro, nzira yacho yakanyatsosimbiswa uye inogona kushandiswa zvakanyanya mukurapa.
(Zviri muchinyorwa ichi zvakadhindwa patsva, uye isu hatipe chero vimbiso yechokwadi, kuvimbika kana kuzara kwezviri muchinyorwa chino, uye hatina mhosva yemafungiro echinyorwa ichi, ndapota nzwisisa.)
Nguva yekutumira: Jul-28-2022