Androgenic alopecia (AGA) imhando yakajairika yekurasikirwa kwebvudzi kunokonzerwa nenhaka uye mahormone, ayo anoratidzwa nekutetepa kwebvudzi remusoro.Pakati pemakore makumi matanhatu, 45% yevarume uye 35% yevakadzi vari kutarisana nedambudziko reAGA.FDA yakatenderwa AGA kurapwa mapuroteni anosanganisira oral finasteride uye topical minoxidil.Parizvino, nekuda kwekushaikwa kwekurapa kunoshanda, PRP yave nzira itsva uye inovimbisa imwe nzira yekurapa.Nhamba huru yekukura kwezvinhu muPRP inogona kukurudzira kuvandudzwa kwebvudzi uye platelet α Zvimwe zvakasiyana-siyana zvekukura zvakavanzwa nemagranules anoita pamasero emasero mubvudzi rebvudzi rinoputika nzvimbo uye rinokurudzira kuumbwa kwemidzi mitsva yeropa.Kunyange zvazvo zvinyorwa zvakawanda zvakashuma izvi, hapana purogiramu yakaenzana yekugadzirira PRP, nzira yehutungamiri uye kuongororwa kwemigumisiro yekliniki.Ichi chinyorwa chine chinangwa chekuongorora kushanda kwePRP mukurapa kweAGA uye kuongorora marapirwo akasiyana-siyana aripo.
Chiito chePRP:
PRP inoshandiswa mushure mekuiswa jekiseni mumusoro kuti isunungure nhamba huru yekukura kwezvinhu uye kukurudzira kukura kwebvudzi.Izvi zvinhu zvinokura zvinogona kumisa fibroblasts, kusimudzira collagen synthesis, kunatsiridza extracellular matrix secretion uye kutonga kutaura kwe endogenous kukura zvinhu.Kukura kwezvinhu (PDGF, TGF- β, VEGF, EGF, IGF-1) inogona kukurudzira kupararira kwesero uye kusiyanisa, chemotactic stem masero, inokonzera kukura kwebvudzi refu, uye kukurudzira bvudzi follicle angiogenesis.Zvimwe zvinhu (serotonin, histamine, dopamine, calcium uye adenosine) zvinogona kuwedzera membrane permeability uye kugadzirisa kuzvimba.
PRP kugadzirira:
Zvose zvirongwa zvekugadzirira PRP zvinotevera mutemo mukuru, uye anticoagulants (yakadai secitrate) inowedzerwa kuropa rakaunganidzwa kuti rirege kuvharidzira coagulation uye platelet activation.Centrifuge kubvisa masero matsvuku eropa uye kuisa pfungwa pamaplatelet.Pamusoro pezvo, zvirongwa zvakawanda zvinosarudza exogenous platelet activators (senge thrombin uye calcium chloride) kukurudzira kukurumidza kuburitswa kwezvinhu zvinokura kubva kumaplatelet nenzira inotsamira yedosi.Inactivated platelets inogonawo kushandiswa nedermal collagen kana autothrombin.Kazhinji, kushingaira kukura chinhu chinovanzwa maminetsi gumi mushure mekuita, uye 95% yeiyo synthesized kukura chinhu inoburitswa mukati meawa imwe, inogara kwevhiki 1.
Chirongwa chekurapa uye kuisa pfungwa:
PRP inowanzo jekiseni pasi pecutaneously kana intradermally.Parizvino, iyo yakakwana yekurapa frequency uye nguva haisati yasimbiswa.Iko kusungirirwa kwePRP chinhu chakakosha chinokanganisa mhedzisiro yekiriniki.Zvinyorwa zvinomwe zvinosanganisira kuisa mberi kuti iyo yakakwana yePRP ndeye 2 ~ 6 nguva, uye kunyanya kuisa pfungwa kunodzivisa angiogenesis.Pachine makakatanwa pamusoro pekuti ine masero machena eropa here.
Mhedzisiro yezvino tsvakiridzo inoratidza izvozvoPRP inogona kushandiswa mukurapa kweAGA.Zvidzidzo zvinomwe zvezvipfumbamwe zvakatsanangura migumisiro yakanaka.Kubudirira kwePRP kwakaongororwa kubva kune dzakawanda maonero: PTG yekuona nzira, bvudzi tension test, hair count uye hair density, nguva yekukura kusvika kune imwe nguva yekuzorora, uye kuongorora kugutsikana kwevarwere.Zvimwe zvidzidzo zvakangotaura nezvekuvandudzwa kwemwedzi we3-kutevera mushure mekurapa kwePRP, asi yakashaya 6-mwedzi yekutevera migumisiro.Zvimwe zvidzidzo zvekutevera kwenguva refu (6 kusvika kumwedzi ye12) zvakashuma kuderera kwebvudzi density, asi yakanga ichiri yakakwirira kudarika yekutanga.Migumisiro yakataurwa chete sekurwadziwa kwenguva pfupi munzvimbo yejekiseni.Hapana maitiro asina kunaka akashumwa.
Kurapwa kunokurudzirwa:
Sezvo PRP isingadziviriri huwandu hwehomoni hunoenderana neAGA, zvinokurudzirwa kuti PRP ishandiswe seadjuvant therapy yeAGA.Nokudaro, varwere vanofanira kukurudzirwa kuchengetedza mishonga yepamusoro kana yemuromo (yakadai seminoxidil, spironolactone uye finasteride).Zvichienderana nechidzidzo ichi chekare, zvinokurudzirwa kugadzirira P-PRP (leukopenia) nekambiso 3-6 nguva yeropa rose.Kushandiswa kwemagetsi (calcium chloride kana calcium gluconate) isati yarapwa inobatsira kusunungura zvinhu zvekukura.Zvinokurudzirwa kuti jekiseni re subcutaneous riitwe kubva pachikamu chine bvudzi shoma, pamwe nebvudzi uye pamusoro, uye nzvimbo dzejekiseni dzinofanira kuparadzaniswa.Mushonga wejekiseni unotarwa nezvido zvekiriniki.Iyo jekiseni frequency inosarudzwa kwekutanga kosi yekurapa (kamwe pamwedzi, katatu muhuwandu, mwedzi mitatu), uyezve kamwe mumwedzi mitatu yega yega, katatu muhuwandu (kureva, kamwe munaJune, Gunyana naDecember zvichiteerana).Ehezve, mushure mekutanga kosi yekurapa, inoshandawo kushandura nguva yepakati kusvika kamwe chete mwedzi mitanhatu.Muzhinji, varwere vechirume nevechikadzi vakawana mhedzisiro yakanaka mukukura kwebvudzi, kuwedzera kwebvudzi kuwedzera uye hupenyu hwekuvandudzwa kwehupenyu mushure mekujova PRP kurapa AGA (Mufananidzo 1 uye Mufananidzo 2).
Mhedziso:
Ongororo yezvakati wandei tsvakurudzo mhinduro inoratidza kuti PRP iri kuvimbisa mukurapa kweAGA.Panguva imwecheteyo, kurapwa kwePRP kunoratidzika kunge kwakachengeteka uye kushoma mhedzisiro.Zvisinei, kuchine kushayikwa kwemaitiro ekugadzirisa PRP nzira, kusungirirwa, chirongwa chejekiseni, chiyero, nezvimwewo. Nokudaro, zvakaoma kuongorora kushanda kwekliniki yePRP.Kuti uenderere mberi nekudzidza mhedzisiro yePRP pakuvandudzwa kwebvudzi muAGA, yakakura saizi yemuenzaniso we randomized controlled trial (ona iyo jekiseni frequency, PRP concentration, uye kubudirira kwenguva refu yekutevera) inodiwa.
(Zviri muchinyorwa ichi zvakadhindwa patsva, uye isu hatipe chero vimbiso yechokwadi, kuvimbika kana kuzara kwezviri muchinyorwa chino, uye hatina mhosva yemafungiro echinyorwa ichi, ndapota nzwisisa.)
Nguva yekutumira: Zvita-08-2022