Androgenic alopecia (AGA), rudzi runonyanya kuzivikanwa rwekurasikirwa kwebvudzi, chirwere chinoenderera mberi chekurasikirwa nebvudzi chinotanga mukuyaruka kana kunonoka kuyaruka.Huwandu hwevarume munyika yangu hunosvika 21.3%, uye huwandu hwevakadzi hunosvika 6.0%.Kunyangwe dzimwe nyanzvi dzakaronga nhungamiro dzekuongororwa uye kurapwa kwe androgenetic alopecia muChina munguva yakapfuura, ivo vanonyanya kutarisa nezve kuongororwa uye kurapwa kweAGA, uye dzimwe nzira dzekurapa dziri kushomeka.Mumakore achangopfuura, nekusimbisa kurapwa kweAGA, dzimwe nzira nyowani dzekurapa dzakabuda.
Etiology uye Pathogenesis
AGA i genetically predisposed polygenic recessive disorder.Domestic epidemiological surveys inoratidza kuti 53.3% -63.9% yevarwere veAGA vane nhoroondo yemhuri, uye mutsara wababa wakakwirira zvikuru kupfuura mutsara waamai.Ikozvino yakazara-genome sequencing uye mepu zvidzidzo zvakaratidza akati wandei susceptibility majini, asi iwo pathogenic majini haasati aonekwa.Tsvakurudzo yemazuva ano inoratidza kuti androgens inoita basa rakasimba mune pathogenesis yeAGA;zvimwe zvinhu zvinosanganisira kuzvimba kwakatenderedza follicle yebvudzi, kuwedzera kumanikidzwa kwehupenyu, kushushikana uye kufunganya, uye mararamiro asina kunaka uye madyiro anogona kuwedzera zviratidzo zveAGA.Androgens muvarume kunyanya inobva ku testosterone yakavanzwa nema testes;androgens mumadzimai anonyanya kuuya kubva mukugadzirwa kweadrenal cortex uye zvishoma zvekuvanda kubva kumaovari, androgen inonyanya kunzi androstenediol, iyo inogona kugadziriswa mu testosterone uye dihydrotestosterone.Kunyange zvazvo androgens iri chinhu chakakosha pathogenesis yeAGA, iyo inotenderera androgen mazinga munenge vese varwere veAGA inochengetedzwa pamazinga akajairika.Zvidzidzo zvakaratidza kuti maitiro e-androgens pamakumbo ebvudzi anowedzera anowedzera nekuda kwekuwedzera uyerogen receptor gene kutaura uye / kana kuwedzera kwekutaura kwerudzi rwechipiri II 5α reductase gene mumakumbo emvere munzvimbo yealopecia.Kune AGA, iyo dermal component cell of susceptible hair follicles ine chaiyo type II 5α reductase, iyo inogona kushandura androgen testosterone inotenderera munzvimbo iri muropa kune dihydrotestosterone nekusunga kune intracellular androgen receptor.Kutanga nhevedzano yezvinoitika zvinotungamira mukufambira mberi miniaturization yebvudzi follicles uye kurasikirwa kwebvudzi kusvika pamhanza.
Makiriniki Manifestations uye Kurapa Kurudziro
AGA imhando yealopecia isina mavanga iyo inowanzotanga munguva yekuyaruka uye inoratidzwa nekuderera kunowedzera kwebvudzi dhayamita, kupera kwebvudzi density, uye alopecia kusvikira mhanza yakasiyana-siyana, kazhinji inoperekedzwa nezviratidzo zvekuwedzera kwemafuta emumusoro.
PRP application
Iro platelet concentrate yakaenzana ne 4-6 times the platelet concentration muropa rose.Pane imwe nguva PRP inoshandiswa, α granules mumaplatelet ichasunungura nhamba yakawanda yekukura kwezvinhu, kusanganisira platelet-derived growth factor, kushandura kukura-β, insulin-like growth factor, epidermal growth factor uye vascular endothelial growth factor, nezvimwewo. yekusimudzira follicle yebvudzi kukura, asi iyo chaiyo nzira yekuita haina kunyatsojeka.Iko kushandiswa ndeyekupinza PRP munharaunda mu dermis layer ye scalp munzvimbo ye alopecia, kamwe chete pamwedzi, uye majekiseni anopfuurira 3 kusvika ku6 nguva anogona kuona imwe mhedzisiro.Kunyange zvazvo zvidzidzo zvakasiyana-siyana zvemakiriniki kumba nekune dzimwe nyika zvakambosimbisa kuti PRP ine imwe mhedzisiro paAGA, hapana chiyero chakafanana chekugadzirira kwePRP, saka chiyero chinoshanda chePRP kurapwa hachisi yunifomu, uye inogona kushandiswa semubatsiri. zvinoreva kurapwa kweAGA panguva ino.
(Zviri muchinyorwa ichi zvakadhindwa patsva, uye isu hatipe chero vimbiso yechokwadi, kuvimbika kana kuzara kwezviri muchinyorwa chino, uye hatina mhosva yemafungiro echinyorwa ichi, ndapota nzwisisa.)
Nguva yekutumira: Aug-02-2022