The half moon board is fibrous cartilage iri mukati nekunze majoini etibial platform.Iwo akasiyana siyana echikadzi uye kusaenzana kweiyo biomechanics anogona kusangana akasiyana mechanics zvinodiwa zvemabvi akabatanidzwa, sekutakura mutoro, kuchengetedza kurongeka kwemabvi, kusimba maekisesaizi, uye kubata kuvhunduka.Kana kukuvara kwehafu yemwedzi kusingakwanisi kurapwa munguva, inowanzokonzera osteoarthritis, uye chikonzero chikuru chekubvunzurudza kwemurwere ndechokuti kurwadziwa kunowedzera uye kusashanda.Iyo hafu yemwedzi bhodhi inogona kukamurwa munzvimbo nhatu dzinotevera, dzinoti nzvimbo chena, nzvimbo tsvuku uye tsvuku uye chena muganhu.Ikoko hakuna kugoverwa kwemidziyo yeropa munzvimbo chena, uye ropa remunharaunda haripiwi.Kamwe kukuvara kwakaoma kupedzisa kugadziriswa kwetishu.Nokudaro, zvakaoma kugadzirisa mushure mekukuvara kwehafu yemwedzi bhodhi, uye varwere vakawanda vane hurombo husina kunaka.Mumakore achangopfuura, nekuenderera mberi kwekuvandudza tekinoroji yekurapa, nzira dzebiochemical dzinokurudzira kugadziriswa kwehafu yemwedzi wekuparidzirwa dzakashandiswa zvakanyanya mukiriniki uye dzakaratidza zvakanakira zvinogona.Plateau plasma plasma (PRP) inogona kuwedzera kugona kwe semi-moon plate fibrocytocytes nenzvimbo chena dzema cartilage masero kusimudzira kupora kwetishu uye kuwana mhedzisiro yakakosha.
Hunhu hwehalf moon board damage
1) Iyo anatomy uye basa remabvi hafu yemwedzi bhodhi
Sefiber cartilage plate, hafu yemwedzi bhodhi iri pakati petibial platform uye femoral cricket mumabvi akabatanidzwa.Maitiro ekuonekwa kwehafu yemwedzi bhodhi ndeaya anotevera: C -yakaumbwa mukati merutivi uye O -yakaumbwa kunze;nzvimbo yekumusoro yakanyura, nzvimbo yepasi yakati sandara;Connect.Mukuwedzera, iyo hafu yemwedzi bhodhi inogona kusungirirwa kumucheto wetibial platform nerubatsiro rwekunze coronary ligament uye inobatanidza kune yakakomberedza mabvi capsule, nepo router tendon inogona kupfuura nekunze uye yakabatana capsules yehafu yemwedzi plate. .Nemhaka yokuti hafu yemwedzi ndiro ropa rinopiwa chete nemucheka wakapoteredza, kana ganda rakapoteredza rakuvadzwa, ndiro yehafu yemwedzi inotarisana necrosis, iyo inokanganisa basa remabvi.
2) Nzira yekukuvara kwemabvi hafu yemwedzi bhodhi
Ibvi revakuru rakabatana hafu yemwedzi bhodhi rinogona kukonzera kukanganisa nekuda kwezvinhu zvakawanda zvekunze zvakaita sezera, basa uye kusimba kwebasa.Varwere vane vechidiki vanowanzobvarurwa, nepo varwere vane uremu vanowanzova nehukama hwepedyo nekushanduka kwekuchinja.Kuderera kwehafu yehafu yeplate yemwedzi kunogona kutungamirira pakuderera kwesimba rayo, izvo zvinotungamirira pakuwedzera kwekugona kwekukuvara.Naizvozvo, kurovedza muviri kusingafungiri kunogona kukonzera kukuvara kwehafu yemwedzi.Kana mabvi akabatanidzwa basa, kukuvara kwehafu yemwedzi kune hukama nekufamba kwehukama hwayo kumabvi akabatanidzwa.Kana mabvi akabatanidzwa akatwasuka, hafu yemwedzi bhodhi inoenda mberi;apo mabvi akabatanidzwa anoshanduka, ndiro yehafu yemwedzi inofamba ichidzokera shure;uye kana mabvi akabatanidzwa achigadziriswa, kunze, kana mukati kutenderera kwemukati, Gare gare kufamba.Kana mabvi akabatanidzwa akangoerekana atendeuka uye anotenderera, hafu yemwedzi mapepa kumativi ose maviri ichava nemabasa anopesana, kureva, "half moon board contradiction movement".
3) Kuongororwa uye kuiswa kwehafu yemwedzi bhodhi kukuvara
Vazhinji vevarwere vane kukuvara kwehafu yemwedzi vane nhoroondo yekushungurudzika kwemabvi.Kiriniki inowanzonyunyuta zviratidzo zvekurwadziwa kwemabvi, kuzvimba, uye kusununguka.Chokutanga pane zvose, periphery ye semi moon plate ine nhamba huru yetsinga peripherals inosanganisira marrow free nerve fibers uye medullary nerve fibers, saka kukuvara kwehafu yemwedzi kunogona kukonzera marwadzo nyore;chechipiri, mabasa emabvi akabatanidzwa achadhonzwa uye anokurudzirwa ne meniscus, izvo zvichawedzera kukonzera marwadzo.Marwadzo achaitika mukati mehumwe huwandu hwemabvi majoini, uye unyoro hunowedzera kugadziriswa uye hunogumira kune rumwe rudzi rwemagapu akabatana.Mwedzi wemwedzi unogonawo kukonzera kubuda ropa pamwe chete, kubuda ropa, uye kuzvimba kwemajoini.Apo ibvi rinogadziriswa, kuputika kuduku kunogona kuwanikwa kana iwe unobata kukuvara kwekubatana.Basa rekubatanidza ibvi rinogonawo kuperekedzwa nemabhuru kune imwe nzvimbo.Panguva ino, kutsvedza kwehafu yendiro yemwedzi kunogona kukonzera kukuvara kweextrusion.Kune avo vane nhoroondo yakarebesa yenhoroondo yezvekurapa, iyo iri pamusoro pekuita basa uye zvikamu zvakananga zve elasticity zvinogona kukonzerwa.
PRP's biological maitiro nebasa
1) Biological Characteristics
PRP ndeye yakasungirirwa autologous yakazara platelet.Kuenzaniswa nemaplatelet akajairwa, kusungirirwa kwayo kuri 4-5 nguva yakakwirira.High concentration yeplatelet ine coordinase uye calcium ions Iyo inoyerera gels inoumbwa inonzi richer platelet gels, iyo inogona kutora chikamu mukugadzwa kweiyo sero bazi rekuvaka.PRP ine marudzi akawanda eprotein uye cytokines, akadai seyakajairika platelet derivative growth factor (PDGF), vascular endothelial growth factor (VEGF), uye fibrin.I-alpha particles yakabudiswa mushure mekukura kwezvinhu zvinogona kuita basa rekugadzirisa, nokudaro kukurudzira kuporesa kwepfupa uye kuvakazve kwevascular reconstruction.PRP ine mapuroteni anokurudzira cartilage cell cell adhesion, nekudaro kuve nechokwadi chekugadzirisa matishu.PRP inoparadzaniswa neropa re autologous, uye kuchengetedzwa kwayo kwakasimbiswa nedzidziso uye yakabatana yemhuka yekuedza.PRP haisi yakachengeteka chete, asi inewo maitiro ekugadzirisa zvipenyu zvipenyu, izvo zvine zvakakosha kugadzirisa zvinokonzerwa nekatekete uye kukuvara kwenyama.
2) Kuwedzera maitiro emasero e cartilage
VEGF uye Fiber cell growth factor (FGF) yakabatana nekuvakwazve kwevascular reconstruction.Pasi pechiito cheVEGF, kupararira kwevascular endothelial masero kunogona kubatsira kuumbwa kwemidziyo mitsva yeropa uye kuvandudzwa kwekufambisa kweropa kwenzvimbo yakakanganiswa, nokudaro kukurudzira kuporesa kwenyama.FGF inogonawo kugadzirisa masero kuti akurumidze kupararira kwevascular endothelial cells nekugadzirisa masero.Hepatocyte growth factor (HGF) inogona kushandura zvinhu zvenyukireya-XB (NF-XB), leukocyte (IL) -1 kuti inhibisa mhinduro yekuputika kwechondrocytes.Iko mukati fiber protein molecular content yePRP ine yakakwirira.Inogona kuumba 3D grid fiber pasi pekushandiswa kwe coordinase uye calcium ion.Nokudaro, PRP inogonawo kunzi platelet gel.PRP haigoni kungokurudzira kugadziriswa kwehutu, asiwo kupa bhakiti yakasungirirwa ye cartilage anterior cell cell uye inosimudzira kusiyanisa kwayo, izvo zvichabatsira kuumbwa kwepachena cartilage matrix.Zvinogona kuonekwa kuti PRP haisi kungobatsira chete kugadziriswa kwegorofu uye nharaunda yevascular uye kugadzirwa kwemabhakiti e-cartilage fiber, asiwo inokurudzira kusungirirwa uye kutama kwemasero emagetsi ehutu, uyezve kugadzirisa kukanganisa kwehutu.
3) PRP yekuongorora tsvakurudzo pahafu yemwedzi kugadzirisa bhodhi
Dzimwe nyanzvi dzakasarudza tsuro sekuedza, uye mushure mehafu yemwedzi bhodhi kukanganisa kwakaitwa mumabvi ose, tsuro dzakaurayiwa pamavhiki mana uye mavhiki masere, uye maitiro avo ehutano akaongororwa.Chidzidzo chacho chakawana kuti pamasvondo e4, boka rekutonga hafu yemwedzi ndiro rakaumbwa nekubatanidza tishu, izvo zvinogona kuratidzwa sefibrosis yakaoma;uye PRP yeboka rekurapa hafu yemwedzi ndiro chimiro chakaratidza zvakajairika, uye junction tishu yaive nekugadzirisa kuri pachena.Kuumbwa kwesangano.Pamasvondo e8, boka rekutonga rakanga rakazara nemafuta ane fibrous, uye cartilage yehafu-yemwedzi plate haina kuumbwa.Boka rePRP rekurapa raive rakapfuma mufiber muhafu yemwedzi ndiro, iyo yakawedzera zvakanyanya.Panguva imwecheteyo, iyo hafu yemwedzi yeplate tissue inoratidzira mune yakadzikama fibrosis, uye kunyange chikamu chekuporesa chiripo.Imwe ongororo yakawana kuti fibrin mupre-processing PRP inogona kugadzira mesh stent ine polystumin-hydroxylcetic acid cluster.Kana iyo PRP iri centrifuged, uye hafu yemwedzi cartilage chondrocyte inosanganiswa kuti iite 7D mumakonzo asina kupfeka eboka rekuedza, fluorescent microscope kuongorora: Masero e cartilage mushure mekudyara mbeu inogona kunamatira uye yakapararira kumativi ose.Mushure mokunge PRP ichirapwa, nhamba yemasero e cartilage yakawedzera zvikuru.Mhedzisiro yekuongorora ma electron microscopy inoratidza kuti pamabhuraketi ePRP akagadziriswa, masero ecartilage anogona kubatanidzwa kune fiber protein network mushure me24H uye 7D.Pakati pezviitiko zve16 zvekugadzirisa PRP bracket group mice, 6 nyaya dzakaporeswa zvachose, 9 nyaya dzakanga dzisina kukwana, uye 1 nyaya haina kupora, nepo boka rekutonga mbeva harina kuporesa.Zvinogona kuonekwa kuti mushure mokunge PRP ichigadziriswa, masero evanhu akabatanidzwa ehuturu ane maitiro chaiwo ekunamatira, izvo zvinogona kuwedzera hafu yemwedzi bhodhi kuporesa kukwanisa.In vitro uye in vitro bvunzo yekutsvaga, ichienzaniswa neiyo nyore PRP gel boka, iyo PRP-osteoma matrix cell gel kurapwa boka ine yakakwirira dhigirii yekusiyanisa.bone.Pane zvidzidzo pane zvakasanganiswa PRP kugadzirisa yeJackie Daping modhi yetsuro cartilage, uye chengetedza iyo cartilage yakaremara nzvimbo passive kufamba.Mhedzisiro yeiyo immunohistochemistry uye yekutadza kuongorora bvunzo yakasimbisa kuti zvibodzwa zvekugadzirisa zvibodzwa zvakakwirira.Chigumisiro chinoratidza kuti PRP inobata basa rinokosha mukugadzirisa marara, uye kushandiswa kwakasanganiswa kwekushandiswa kwekubatana kwekushandiswa kwemapfupa emapfupa mesenchymal stem masero uye bhakiti zvinhu zviri nani.
(Zviri muchinyorwa ichi zvakadhindwa patsva, uye isu hatipe chero vimbiso yechokwadi, kuvimbika kana kuzara kwezviri muchinyorwa chino, uye hatina mhosva yemafungiro echinyorwa ichi, ndapota nzwisisa.)
Nguva yekutumira: May-11-2023