PRP inobata ne degranulation ye alpha granules kubva kumaplatelet, ane akati wandei ekukura zvinhu.Active secretion yeizvi kukura zvinhu inotangwa neropa coagulation process uye inotanga mukati me10 maminetsi ekubatana.Kupfuura 95% yepre-synthesized kukura zvinhu zvinovanzwa mukati meawa imwe.Nokudaro, PRP inofanira kugadzirirwa mune anticoagulant state uye inofanira kushandiswa muzvikamu, zviputi, kana maronda mukati memaminitsi e10 ekuvhara ropa.Zvidzidzo zvisingashandisi anticoagulated ropa rose hazvisi zvechokwadi zvidzidzo zvePRP uye zvinotsausa.
Sezvo maplatelet achiitwa nekugwamba, kukura kwezvinhu zvinovanzwa kubva musero kuburikidza nesero membrane.Mukuita uku, ma alpha particles anovhengana kune platelet cell membranes, uye mapuroteni ekukura zvinhu anopedzisa bioactive mamiriro nekuwedzera histone uye carbohydrate parutivi cheni kune aya mapuroteni.Nokudaro, maplatelet akakuvadzwa kana kusagadziriswa nePRP kurapwa haabudisi bioactive kukura zvinhu uye zvinogona kutungamirira kumigumisiro inoodza mwoyo.Chakavanzika chekukura zvinhu zvinosunga nekukasira kune yekunze pamusoro pe membrane yemasero mugraft, flap, kana ronda kuburikidza ne transmembrane receptors.
Zvidzidzo zvakaratidza kuti munhu mukuru mesenchymal stem masero, osteoblasts, fibroblasts, endothelial masero, uye epidermal masero anoratidza cell membrane receptors yekukura zvinhu muPRP.Aya ma-transmembrane receptors anozoita kuti aite activation ye endo native yemukati masaini mapuroteni anotungamira kune kutaura (kuvhura) kweakajairika cellular gene sequences, sekuwanda kwesero, matrix formation, osteoid formation, collagen synthesis, nezvimwe.
Kukosha kweruzivo urwu ndekwekuti PRP kukura zvinhu hazvipindi musero kana nucleus yayo, hazvisi mutagenic, zvinongowedzera kukurudzira kupora kwakajairika.Naizvozvo, PRP haina kugona kukurudzira kuumbwa kwebundu.
Mushure mekuputika kwekutanga kwePRP-yakabatana nekukura zvinhu, maplatelet anogadzira uye anobudisa zvimwe zvinhu zvekukura kwemazuva manomwe asara ehupenyu hwavo.Kana maplatelet apera uye afa, macrophages anosvika mudunhu kuburikidza neropa-anomutswa tsinga dzeropa dzinokura mukati kuti dzitore basa rekudzora maronda nekuvanza zvimwe zvakafanana zvekukura pamwe nezvimwe.Nokudaro, nhamba yemaplatelet ari mugraft, ronda, kana kuti ropa rakavharwa pajira rinotarisa kuti ronda racho rinokurumidza sei kupora.PRP inongowedzera kune iyo nhamba.
Ingani maplatelet anokwana?
Zvidzidzo zvakaratidza kuti kuwanda uye kusiyanisa kwevakuru veMSCS kune hukama hwakananga nekusungwa kweplatelet.Vakaratidza dose-response curves, izvo zvakaratidza kuti kukwana kweserura kupindurwa kweplatelet concentration yakatanga apo mana kusvika kashanu nhamba yekutanga yeplatelet yakasvika.Chidzidzo chakafanana chakaratidza kuti kuwedzera kwehuwandu hweplatelet kwakasimudzirawo kuwedzera kwefibroblast uye mhando I collagen kugadzirwa, uye kuti yakawanda yemhinduro yaive PH-inotsamira, nemhinduro yakanakisa inoitika kune yakawanda acidic pH mazinga.
Zvidzidzo izvi hazvingoratidzi kudikanwa kwemidziyo yekuisa pfungwa dzakakwana dzeplatelet, asi zvakare inotsanangura iyo yakagadziridzwa mapfupa ekuvandudza mhedzisiro uye yakagadziridzwa yakapfava mhedzisiro yakabatana nePRP.
Sezvo vanhu vazhinji vaine nhamba yekutanga yeplatelet ye200,000 ± 75,000 pa μl, nhamba yePRP yeplatelet yemiriyoni imwe pa μl yakayerwa mune yakajairwa 6-ml aliquots yave mucherechedzo we "rapeutic PRP."Zvakakosha, zvidzidzo zvakaratidza kuti iyi platelet concentration inowanikwa kana mazinga ekurapa asvika, nekudaro achiburitsa zvinhu zvekukura.
(Zviri muchinyorwa ichi zvakadhindwa patsva, uye isu hatipe chero vimbiso yechokwadi, kuvimbika kana kuzara kwezviri muchinyorwa chino, uye hatina mhosva yemafungiro echinyorwa ichi, ndapota nzwisisa.)
Nguva yekutumira: Sep-01-2022