Platelets, sezvimedu zvemasero kubva kumapfupa emapfupa megakaryocytes, zvinoratidzirwa nekusavapo kwema nuclei.Imwe neimwe platelet ine marudzi matatu ezvimedu, zvinoti α Granules, miviri yakakora uye lysosomes ane huwandu hwakasiyana.Kusanganisira α Iwo magranules akapfuma mune anopfuura 300 mapuroteni akasiyana, akadai sevascular endothelial activating factor, leukocyte chemotactic factor, activating factor, tissue repair inoenderana nekukura factor uye antibacterial peptide, iyo inobatanidzwa mune dzakawanda zvemuviri uye pathological process, senge ronda kuporesa. , angiogenesis uye anti infection immunity.
Muviri wakaoma une huwandu hwakawanda hweadenosine diphosphate (ADP), adenosine triphosphate (ATP), Ca2+, Mg2 + uye 5-hydroxytryptamine.Lysosomes ine zvakasiyana-siyana zveshuga proteases, zvakadai se glycosidases, proteases, cationic mapuroteni uye mapuroteni ane bactericidal basa.Aya maGF anoburitswa muropa mushure mekushandiswa kweplatelet.
GF inokonzeresa maitiro ekuita nekusunga nemhando dzakasiyana dzesero membrane receptors, uye inomisikidza mamwe mabasa mukuita kutsva kwetishu.Parizvino, iyo inonyanya kudzidza GF iplatelet derived growth factor (PDGF) uye kushandura kukura chinhu (TGF- β (TGF- β) , Vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), fibroblast growth factor (FGF), connective tissue growth factor (CTGF) and insulin-like growth factor-1 (IGF-1) maGF aya anobatsira kugadzirisa tsandanyama, tendon, ligament nemamwe matissue kuburikidza nekusimudzira kupararira kwesero nekusiyanisa, angiogenesis nemamwe maitiro, uyezve kutamba inowirirana. basa.
Kushandiswa kwePRP muVitiligo
Vitiligo, seyakajairika autoimmune chirwere, pamwe nevhoriyamu yakaremara chirwere cheganda, ine mhedzisiro yakaipa pane psychology yevarwere uye yakakanganisa zvakanyanya hupenyu hwevarwere.Kupfupisa, kuitika kwevitiligo mhedzisiro yekudyidzana kweiyo genetic zvinhu uye zvakatipoteredza zvinhu, izvo zvinoita kuti ganda melanocytes rirwiswe uye kukuvadzwa ne autoimmune system.Parizvino, kunyangwe paine marapirwo mazhinji evitiligo, kushanda kwawo kunowanzo kuve kwakashata, uye marapirwo mazhinji haana humbowo hwehumbowo hwemishonga.Mumakore achangopfuura, nekuenderera mberi kwekuongorora kwepathogenesis yevitiligo, dzimwe nzira itsva dzekurapa dzakagara dzichishandiswa.Senzira inoshanda yekurapa vitiligo, PRP yagara ichiiswa.
Parizvino, 308 nm excimer laser uye 311 nm narrow band ultraviolet (NB-UVB) uye mamwe matekinoroji ephototherapy ari kuwedzera kuzivikanwa nekuda kwekushanda kwawo muvarwere vane vitiligo.Parizvino, kushandiswa kwe autologous PRP subcutaneous microneedle jekiseni pamwe chete ne phototherapy kune varwere vane vitiligo yakagadzikana yakafambira mberi zvikuru.Abdelghani et al.vakawana mutsvakurudzo yavo kuti autologous PRP subcutaneous microneedle jekiseni rakasanganiswa neNB-UVB phototherapy rinogona kupfupisa nguva yose yekurapa kwevarwere vevitiligo.
Khattab et al.vakarapa varwere vane yakagadzikana isiri segmental vitiligo ine 308 nm excimer laser uye PRP, uye vakawana mhedzisiro yakanaka.Zvakaonekwa kuti musanganiswa wezviviri izvi zvinogona kunyatso kuvandudza chiyero cheleucoplakia recolor, kupfupisa nguva yekurapa, uye kudzivirira kuita kwakashata kwekushandiswa kwenguva refu kwe308 nm excimer laser irradiation.Zvidzidzo izvi zvinoratidza kuti PRP yakasanganiswa nephototherapy inzira inoshanda yekurapa vitiligo.
Zvisinei, Ibrahim nezvimwe zvidzidzo zvakare zvinoratidza kuti PRP chete haibatsiri mukurapa kwevitiligo.Kadry et al.yakaita ongororo yakarongeka yakaitwa pakurapa vitiligo nePRP yakasanganiswa necarbon dioxide dot matrix laser, uye yakaona kuti PRP yakasanganiswa necarbon dioxide dot matrix laser uye PRP chete yakanga yawana yakanaka kubereka kwemavara.Pakati pavo, PRP yakasanganiswa necarbon dioxide dot matrix laser yaiva nemhando yakanakisisa yekuberekwa kwemavara, uye PRP chete yakanga yawana kubereka kwemavara ane mwero mu leukoplakia.Iko kubereka kwemavara kwePRP chete kwaive nani pane iyo carbon dioxide dot matrix laser chete mukurapa vitiligo.
Kushanda Kunosanganiswa nePRP muKurapa kweVitiligo
Vitiligo rudzi rwechirwere chepigment chinoratidzirwa nekubuda kwepigmentation.Nzira dzechinyakare dzekurapa dzinosanganisira kurapa kwezvinodhaka, phototherapy kana kuvhiyiwa, kana musanganiswa wenzira dzakawanda dzekurapa.Kune varwere vane vitiligo yakagadzikana uye yakashata yehutano hwemazuva ose, kurapwa kwekuvhiya kunogona kuva kupindira kwekutanga.
Garg et al.yakashandisa PRP semumiriri wekumisa epidermal masero, uye akashandisa Er: YAG laser kukuya mavara machena, ayo akawana yakanaka kurapa mhedzisiro mukurapa kwakagadzikana vitiligo varwere.Muchidzidzo ichi, varwere gumi vane vitiligo yakagadzikana vakanyoreswa uye maronda makumi maviri akawanikwa.Mumaronda e20, zvipembenene zve 12 (60%) zvakaratidza kupora kwakakwana kwepigment, 2 zvipembenene (10%) zvakaratidza kupora kukuru kwepigment, 4 zvipembenene (20%) zvakaratidza kupora kwepigment zvine mwero, uye 2 zvipembenene (10%) zvakaratidza kusakosha kukuru.Kudzorerwa kwemakumbo, majoini emabvi, chiso nemutsipa zvinonyanya kuoneka, nepo kudzoreredzwa kwemigumo kwakashata.
Nimitha et al.yakashandisa PRP kumiswa kwemasero epidermal kugadzirira kumiswa uye phosphate buffer kusimiswa kwemasero epidermal kuenzanisa nekucherechedza kupora kwavo pigment kune varwere vane vitiligo yakagadzikana.Varwere 21 vakatsiga vevitiligo vakaiswa uye 42 mavara machena akawanikwa.Avhareji yakagadzikana nguva yevitiligo yaive makore 4.5.Vazhinji varwere vakaratidza kutenderera kudiki kune oval discrete pigment kupora anenge mwedzi 1-3 mushure mekurapwa.Pakati pemwedzi ye6 yekutevera, iyo inonzi pigment recovery yaiva 75.6% muboka rePRP uye 65% muboka risiri rePRP.Musiyano wenzvimbo yekudzoreredza pigment pakati peboka rePRP uye isiri PRP boka raive nenhamba yakakosha.PRP boka rakaratidza zviri nani pigment kupora.Pakuongorora pigment kupora chiyero muvarwere vane segmental vitiligo, pakanga pasina misiyano yakakosha pakati peboka rePRP uye risiri PRP boka.
Kushandiswa kwePRP muChloasma
Melasma rudzi rwechirwere cheganda chakawanikwa chechiso, chinowanzoitika pachiso chevakadzi vanogara vachioneswa ultraviolet mwenje uye vane yakadzika ganda ruvara.Pathogenesis yaro haina kunyatsojekeswa, uye yakaoma kurapa uye nyore kudzoka.Parizvino, kurapwa kwechloasma kunonyanya kutora nzira yekurapa yakasanganiswa.Kunyange zvazvo jekiseni rezasi rePRP rine nzira dzakasiyana-siyana dzokurapa chloasma, kushanda kwevarwere hakuna kunyatsogutsikana, uye zviri nyore kudzoka zvakare mushure mokumisa kurapwa.Uye mishonga yemumuromo yakadai setranexamic acid uye glutathione inogona kukonzera kuputika kwedumbu, kusagadzikana kwekuenda kumwedzi, kutemwa nemusoro, uye kunyange kuumbwa kwe-deep vein thrombosis.
Kuongorora mushonga mutsva wechloasma igwara rakakosha mukutsvaga kwechloasma.Zvinonzi PRP inogona kuvandudza zvakanyanya maronda eganda evarwere vane melasma.Cay ı rl ı Et al.yakashuma kuti mukadzi wemakore makumi maviri nemanomwe akagamuchira subcutaneous microneedle jekiseni rePRP mazuva ose e15.Pakupera kwechitatu PRP kurapwa, yakaonekwa kuti nzvimbo yepidermal pigment recovery yaiva> 80%, uye pakanga pasina kudzoka zvakare mukati memwedzi ye6.Sirithanabadeekul et al.yakashandisa PRP yekurapa kwechloasma kuita zvakanyanya kusimba RCT, iyo yakawedzera kusimbisa kushanda kweiyo intracutaneous PRP jekiseni pakurapa kwechloasma.
Hofny et al.yakashandisa immunohistochemical nzira yekuita TGF kuburikidza ne subcutaneous microneedle jekiseni yePRP mumaronda eganda evarwere vane chloasma uye zvikamu zvakajairika- β Kuenzanisa kweprotein kutaura kwakaratidza kuti pamberi pePRP kurapwa, zvipembenene zveganda zvevarwere vane chloasma uye TGF zvakapoteredza zvipembenene zveganda- β Kutaura kweprotein kwakaderera zvakanyanya kudarika kweganda rine utano (P <0.05).Mushure mekurapa kwePRP, TGF yezvipembenene zveganda kune varwere vane chloasma- β Kuratidzwa kweprotein kwakawedzera zvakanyanya.Ichi chiitiko chinoratidza kuti kuvandudzwa kwePRP pavarwere vechloasma kunogona kuwanikwa kuburikidza nekuwedzera TGF yezvipembenene zveganda- β Iprotein expression inobudirira kurapa kwechloasma.
Photoelectric Technology Yakasanganiswa ne Subcutaneous Injection yePRP yeKurapwa kweChloasma
Nekuenderera mberi kwekuvandudza tekinoroji yefotoelectric, basa rayo mukurapa kwechloasma rakakwezva kutarisisa kwakawanda kwevaongorori.Parizvino, ma lasers anoshandiswa kurapa chloasma anosanganisira Q-switched laser, lattice laser, intense pulsed light, cuprous bromide laser uye mamwe matanho ekurapa.Nheyo yacho ndeyokuti kusarudzwa kwechiedza chinoputika kunoitwa nokuda kwezvikamu zve melanin mukati kana pakati pe melanocytes kuburikidza nekusarudza simba, uye basa re melanocytes harina kushandiswa kana kuvharwa kuburikidza nesimba rakaderera uye kuputika kwechiedza chakawanda, uye panguva imwe chete, kuputika kwechiedza che melanin particles. inoitiswa, Inogona kuita kuti melanin zvidimbu zvidiki uye zvive nyore kumedzwa nekuburitswa nemuviri.
Su Bifeng et al.yakarapwa chloasma nePRP remvura jekiseni rechiedza rakasanganiswa neQ switched Nd: YAG 1064nm laser.Pakati pevarwere ve100 vane chloasma, varwere ve15 muPRP + laser boka vakanyatsoporeswa, varwere ve22 vakagadziridzwa zvakanyanya, varwere ve11 vakagadziridzwa, uye 1 murwere akanga asina kushanda;Muboka relaser chete, 8 kesi dzakarapwa, makumi maviri neshanu dzakanyanya kushanda, gumi nesere dzakagadziridzwa, uye 3 kesi dzaisashanda.Musiyano pakati pemapoka maviri aya waive wakakosha (P <0.05).Peng Guokai naSong Jiquan vakasimbisazve kushanda kweQ-switched laser yakasanganiswa nePRP mukurapa kwechiso chloasma.Zvigumisiro zvakaratidza kuti Q-switched laser yakasanganiswa nePRP yakashanda mukurapa kwechiso chloasma
Maererano nekutsvakurudza kwemazuva ano pamusoro pePRP mune pigmented dermatoses, iyo inogona kuitika yePRP mukurapa kwechloasma ndeyokuti PRP inowedzera TGF yezvipembenene zveganda- β Kuratidzwa kweprotein kunogona kuvandudza varwere ve melasma.Kuvandudzwa kwePRP pane vitiligo zvironda zveganda zvevarwere zvinogona kunge zvine hukama neiyo α Adhesion mamorekuru anovanzwa nemagranules ane hukama nekuvandudzwa kwenzvimbo diki diki yevitiligo maronda nemacytokines.Kutanga kwevitiligo kwakabatana zvakanyanya nehutachiona husina kunaka hwemaronda eganda.Zvidzidzo zvakawana kuti kusakwana kwekudzivirira kwemuviri kwevarwere vevitiligo kune hukama nekutadza kwekeratinocytes uye melanocytes mumaronda eganda kurwisa kukuvadzwa kwemamelanocytes kunokonzerwa neakasiyana ezviputi zvinhu uye chemokines inoburitswa mukuita intracellular oxidative kusagadzikana.Zvisinei, zvakasiyana-siyana zvekukura kweplatelet zvinhu zvakavanzwa nePRP uye zvakasiyana-siyana zve-anti-inflammatory cytokines zvakaburitswa nemaplatelet, akadai soluble tumor necrosis factor receptor I, IL-4 uye IL-10, iyo inopikisa interleukin-1 receptor, inogona. tamba imwe basa mukugadzirisa hutano hwemunharaunda hwemaronda eganda.
(Zviri muchinyorwa ichi zvakadhindwa patsva, uye isu hatipe chero vimbiso yechokwadi, kuvimbika kana kuzara kwezviri muchinyorwa chino, uye hatina mhosva yemafungiro echinyorwa ichi, ndapota nzwisisa.)
Nguva yekutumira: Nov-24-2022